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Publications:

Dishaw LJ, Leigh B, Cannon JP, Liberti A, Mueller MG, Skapura DP, Karrer CR, Pinto MR, De Santis R, Litman GW. Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria. Nat Commun. 2016 Feb 15;7:10617.

Liberti A, Leigh B, De Santis R, Pinto MR, Cannon JP,
Dishaw LJ, Litman GW. An Immune Effector System in the Protochordate Gut Sheds Light on Fundamental Aspects of Vertebrate Immunity. Results Probl Cell Differ. 2015;57:159-73.

Litman GW, Dishaw LJ. Early histocompatibility: color the mechanism green and red. Curr Biol. 2015 Nov 2;25(21):R1042-3. doi:10.1016/j.cub.2015.09.053.

Fahsbender E, Rosario K, Cannon JP, Gulland F,
Dishaw LJ, Breitbart M. Development of a Serological Assay for the Sea Lion (Zalophus californianus) Anellovirus, ZcAV. Nature Sci Rep. 2015 May 12;5:9637. doi: 10.1038/srep09637.

Zhang L, Li L, Guo X, Litman GW,
Dishaw LJ, Zhang G. Massive expansion and functional divergence of innate immune genes in a protostome. Nature Sci Rep. 2015 Mar 3;5:8693. doi: 10.1038/srep08693.

Groer MW, Luciano AA,
Dishaw LJ, Ashmeade TL, Miller E, Gilbert JA. Development of the preterm infant gut microbiome: a research priority. Microbiome. 2014 Oct 13;2:38. doi: 10.1186/2049-2618-2-38.

Dishaw LJ, Cannon JP, Litman GW, Parker W. Immune-directed support of rich microbial communities in the gut has ancient roots. Dev Comp Immunol. 2014 Nov;47(1):36-51.

Liberti A, Melillo D, Zucchetti I, Natale L, Dishaw LJ, Litman GW, De Santis R, Pinto MR. Expression of Ciona intestinalis variable region-containing chitin-binding proteins during development of the gastrointestinal tract and their role in host-microbe interactions. PLoS One. 2014 May 2;9(5):e94984.

Dishaw LJ, Flores-Torres J, Lax S, Gemayel K, Leigh B, Melillo D, Mueller MG, Natale L, Zucchetti I, De Santis R, Pinto MR, Litman GW, Gilbert JA. The gut of geographically disparate Ciona intestinalis harbors a core microbiota. PLoS One. 2014 Apr 2;9(4):e93386.

Dishaw LJ, Litman GW. Changing views of the evolution of immunity. Front Immunol. 2013 May 21;4:122.

Litman GW,
Dishaw LJ. Histocompatibility: clarifying fusion confusion. Curr Biol. 2013 Oct 21;23(20):R934-5. doi: 10.1016/j.cub.2013.08.048. PubMed PMID: 24156816.

Dishaw LJ,
Flores-Torres JA, Mueller MG, Karrer CR, Skapura DP, Melillo D, Zucchetti I, De Santis R, Pinto MR, Litman GW. A Basal chordate model for studies of gut microbial immune interactions. Front Immunol. 2012;3:96. Epub 2012 May 3. PubMed PMID: 22563328; PubMed Central PMCID: PMC3342567.

Dishaw LJ,
Haire RN, Litman GW. The amphioxus genome provides unique insight into the evolution of immunity. Brief Funct Genomics. 2012 Mar;11(2):167-76. PubMed PMID: 22402506; PubMed Central PMCID: PMC3310213.

Dishaw LJ,
Giacomelli S, Melillo D, Zucchetti I, Haire RN, Natale L, Russo NA, De Santis R, Litman GW, Pinto MR. A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions. Proc Natl Acad Sci U S A. 2011 108(40): 16747-52.

Dishaw LJ,
Mueller MG, Haire RN, Litman GW. Transfection-based genomic readout for identifying rare transcriptional splice variants. Methods Mol Biol. 2011;748:243-54.

Dishaw LJ
, Ota T, Mueller MG, Cannon JP, Haire RN, Gwatney NR, Litman RT, Litman GW. The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus. Immunogenetics. 2010 Sep;62(9):623-31. Epub 2010 Jul 22.

Cannon JP, Dishaw LJ, Haire, RN, Litman RT, Ostrov DA, and Litman GW. 2010. Recognition of additional roles for immunoglobulin domains in immune function. Semin Immunol, 2010 Feb;22(1):17-24. Epub 2009 Dec 8. Review. PubMed PMID: 20004115

Dorsey, MJ., A. Petrovic, M.R. Morrow,
L.J. Dishaw, J.W. Sleasman. 2009. FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Immunol Res, 44(1-3): 179-84.(PMID 19471859)

Dishaw, LJ.
, Litman, G.W. Invertebrate allorecognition: the origins of histocompatibility. 2009. Current Biology, Apr 14; 19(7): R286-288.

Dishaw, L.J
. M. G. Mueller, N. Gwatney, J. P. Cannon, R. N. Haire, R. T. Litman, C. T. Amemiya, T. Ota, L. Rowen, G. Glusman, G, W. Litman. 2008. Genomic Complexity of the Variable Region-Containing Chitin-Binding Proteins in Amphioxus, BMC Genetics, Dec 1;9(1):78. (PMID: 19046437).

Zhang, Q., C.M. Zmasek,
L.J. Dishaw, M.G. Mueller, Y. Ye, , G.W. Litman, A. Godzik.  2008. Novel genes dramatically alter regulatory network topology in amphioxus. Genome Biology, 9(8):R123. Epub 2008 Aug4 (PMID: 18680598).

Holland, L.Z. et al (Bf annotation community), 2008. The amphioxus genome illuminates vertebrate origins and cephalochordate biology.
Genome Research, 18(7): 1100-11 (PMID 18562680).

Litman, G.W., L.J. Dishaw, J.P. Cannon, R.N. Haire, J.P. Rast.  2007.  Alternative mechanisms of immune receptor diversity.  Current Opinion in Immunology, 19(5): 526-534.

Litman G.W., J. P. Cannon, L. J. Dishaw, R. N. Haire, D. D. Eason, J. A. Yoder, J. Hernandez Prada, D. A. Ostrov.  2007. Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors. Immunologic Research: Perspectives in Immunology. 38(1-3): 294-304.

Dishaw, L.J., M.L. Herrera, and C.H. Bigger. 2006.  Characterization and phylogenetic analysis of a Cnidarian LMP X-like cDNA.   Immunogenetics 58 (5-6): 454-464.

Litman, G.W., J.P. Cannon, and
L.J. Dishaw. 2005.  Reconstructing immune phylogeny:  new perspectives,   Nature Reviews Immunology 5(11): 866-879.

Dishaw, L.J., S. L. Smith, and C. H. Bigger. 2005.  Characterization of a C3-like cDNA in a coral:  phylogenetic implications.  Immunogenetics  57(7):  535-548.

Kozmik, Z., M. Daube, E. Frei, B. Norman, L. Kos,
L. J. Dishaw, M. Noll, and J. Piatigorsky.  2003.  Role of Pax Genes in Eye Evolution:  A Cnidarian PaxB Gene Uniting Pax2 and Pax6 Functions.  Developmental Cell 5: 773-785. (Nov. Issue: Cover Photo).

Piatigorsky, J., B. Norman,
L.J. Dishaw, L. Kos, J. Horwitz, P.J. Steinbach, and Z. Kozmik. 2001. J3-crystallin of the jellyfish lens:  Similarity to saposins.  Proceedings of the National Academy of Sciences. USA.  98(22): 12362-67.


Published abstracts and meeting presentations:

Dishaw, L.J. Bacterial communities in the gut: investigating the ‘where’ and the ‘how’ with an alternative model system. USF Dept. of Molecular Medicine, Dept Seminar invited speaker, Oct 2014. (invited talk)

Leigh, B. J. P. Cannon, A. Liberti, C. Karrer, D. Skapura, M.G.Mueller, R. De Santis, M.R. Pinto, G.W. Litman, M. Breitbart, and L. J. Dishaw. A basal model system places ecological principles of human gut bacterial homeostasis within reach. Third Annual, All Children’s Hospital Symposium, Oct. 2014.

Leigh, B. J. P. Cannon, A. Liberti, C. Karrer, G.W. Litman, M. Breitbart, and L. J. Dishaw. The effects of phage on biofilm formation of the Shewanella sp. isolated from the gut of a marine invertebrate, Ciona intestinalis. Southeastern Microbiology Summit-2014. Joint meeting of the Southeaster and Florida ASM Branches, Ponte Vedra, Fl 2014.

Dishaw, L.J. Evidence for compartmentalized regulation of host-bacterial interactions in the gut of Ciona intestinalis. (Full author list: Assunta Liberti, Brittany Leigh, John P. Cannon, M. Gail. Mueller, Charlotte Karrer, Diana Skapura, Rosaria De Santis, Maria Rosaria Pinto, Gary W. Litman, and Larry J.Dishaw), 5th North American Comparative Immunology Workshop (NACI), Albuquerque, NM, 2014. (invited talk)

Martinez-Lopez, D.G., L.J. Dishaw, and A.A. Luciano. Distinct Cord Blood T cell and Inflammatory Characteristics in Preterm Infants who Developed NEC, BPD or Late Onset Sepsis, Pediatric Academic Societies (PAS) Annual Meeting 2014, Denver, CO, USA.

Dishaw, L.J., D.G. Martinez-Lopez, A.A. Luciano. Detection of microbial products in cord blood of preterm infants, Pediatric Academic Societies (PAS) Annual Meeting, 2014, Denver, CO. USA.


Dishaw, L.J. B. Leigh, C. Karrer, G.Mueller, J.P. Cannon, R. De Santis, M.R. Pinto, and G.W. Litman. An invertebrate perspective on the evolution of chordate gut-microbial interactions. Keystone Symposium, A7: Mechanisms and Consequences of Invertebrate-Microbe Interactions, Tahoe City, CA, Jan 2014. (Invited talk; also poster, see below).

Leigh, B., A. Liberti, C. Karrer, G. Mueller, J.P. Cannon, R. De Santis, M. R. Pinto, G.W. Litman and L.J. Dishaw. Selective interactions between host immunity and adherent gut bacteria in Ciona intestinalis. 16th Annual Biomedical and Comparative Immunology Symposium, Florida International University, Miami, FL 2014.

Dishaw, L.J. Phylogenetic interrogation of bacterial homeostasis in the gut. Invited speaker, Tampa Bay’s Tiniest Biology Seminar Series, Nov 12, 2013.

Leigh, B., C. Karrer, G. Mueller, J.P. Cannon, G.W. Litman, and L.J.Dishaw. An invertebrate gut immunoglobulin interacts with adherent communities of bacteria. Second annual, All Children’s Hospital Symposium, Oct 2013

Dishaw, L.J. Phylogenetic interrogation of gut bacterial-immune dynamics suggests critical role(s) for adherent communities, USF Dept. of Molecular Medicine, Dept Seminar invited speaker, Sept 2013.

Dishaw, L.J. What a Spineless Relative is Teaching Us About the Clinical Relevance of Our Microbiome, USF Dept. of Pediatrics, Grand Rounds Seminar, June 2013.

Dishaw, L.J., B. Leigh, C. Karrer, and J. Flores-Torres. Experimental manipulation of gut microbiota in the filter feeding marine invertebrate, Ciona intestinalis. North American Comparative Immunology Workshop, Invited Speaker, 2013.

Leigh, B., C. Karrer, J. Flores-Torres and L.J. Dishaw. VCBPs, chemotaxis, and bacterial colonization of the Ciona gut. North American Comparative Immunology Workshop, 2013.

Flores-Torres, J., B. Leigh, and L.J. Dishaw. Bacterial dysbiosis in an unusual model for studies of intestinal immune homeostasis. Pediatric Academic Societies (PAS) Meeting, Washington, DC, May 2013.

Fahsbender, E., E. Wheeler, F. Gulland, J. Cannon, L.J. Dishaw, M. Breitbart. Development of a Serological Assay for the Novel Zalophus californianus Anellovirus. 31st Annual Graduate Student Symposium, USF College of Marine Sciences. April 2013 (E. Fahsbender, presenting author).

Leigh, B., M. Breitbart, and L.J. Dishaw. Chemotaxis in host gut-microbe interactions. 31st Annual Graduate Student Symposium, USF College of Marine Sciences. April 2013 (B. Leigh, presenting author).

Leigh, B., M. Breitbart, and L.J. Dishaw. Chemotaxis in host gut-microbe interactions. Annual meeting of the Florida Chapter of the American Society for Microbiology. April 2013 (Invited talk, B. Leigh, presenting author).

Dishaw, L.J. Evidence for a core gut microbiome in the filter-feeding marine invertebrate, Ciona intestinalis. 15th Biomedical and Comparative Immunology Symposium at Florida International University, Invited Session Speaker, March 2013.

Flores-Torres, J., B. Leigh, C. Karrer, M. G. Mueller, A. Liberti, D. Melillo, I. Zucchetti, R. De Santis, M.R. Pinto, and G. W. Litman, and L.J. Dishaw. Bacterial dysbiosis in an unusual model for studies of intestinal immune homeostasis. 81st Perinatal & Developmental Medicine Symposium, Naples, Fl, November 2012.

Leigh, B., J. Flores-Torres, K. Gemayel, C. Karrer, M. G. Mueller, A. Liberti, D. Melillo, I. Zucchetti, R. De Santis, M.R. Pinto, G. W. Litman, and L.J. Dishaw. Microbial community complexity in a protochordate model for intestinal immune homeostasis, 4th ASM Congress on Beneficial Microbes, San Antonio, TX. Oct 2012.

Flores-Torres, J., M. Gail Mueller, G.W. Litman, and L.J. Dishaw. An unconventional look at microbial dysbiosis in the gut, USF-Health Research Day, 2012.

Dishaw, L.J. Ciona VCBPs are secreted into the gut lumen, bind bacteria, and are recognized by circulating hemocytes. 14th Biomedical and Comparative Immunology Symposium at Florida International University, Invited Session Speaker, March 1-2, 2012.

Dishaw, LJ. Protochordate VCBPs are involved in the host-microbial dialogue of the gut. 2011. 6th International Tunicate Meeting, Montreal, Ca. Invited Plenary Seminar.

Dishaw, L.J. A protochordate innate immune protein secreted into the gut lumen is involved in host-bacterial dynamics. 2011. Invited Seminar. All Children’s Hospital Research Seminar Series.

Dishaw, LJ. An Invertebrate Model for Gut Commensal/Innate-Immune Interaction studies. 2010. The University of South Florida and University of Florida, Allergy and Immunology Research Retreat. Invited Seminar.

Dorsey, M.J., A. Petrovic, M.R. Morrow, L.J. Dishaw, and J.W. Sleasman. 2007. FoxP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. FOCIS 7th Annual Meeting, Federation of Clinical Immunology Societies, Clinical Immunology, 123 (S1): S43.

Litman G.W.,  
L.J.Dishaw, R.N. Haire, M.G. Mueller., R.T. Litman, N.R. Schnitker, J.P. Cannon.  2006.  Genomic complexity and genetic diversity of an immune-type locus in amphioxus.  Genomics and the Life Aquatic (Sept 9-12, 2006), Friday Harbor Laboratories, University of Washington, USA.

Litman G. W.,  
L. J. Dishaw, J. Hernandez Prada,  N. R. Schnitker, R. N. Haire, M. G. Mueller, R. T. Litman, D. A. Ostrov, J. P. Cannon.  2006.  Diversified variable region-containing chitin-binding proteins in Amphioxus, a Cephalochordate.   10th Congress of the International Society of Developmental and Comparative Immunology, S. Carolina, USA.

Espinal A.D., D.-H. Shin, S. L. Smith,
L.J. Dishaw,  C. H. Bigger.  2006.  Preliminary characterization of a second thiolester protein (TEP) from the Gorgonian coral, Swiftia exserta.  10th Congress of the International Society of Developmental and Comparative Immunology, S. Carolina, USA.

Dishaw, L.J. and G.W. Litman.  2005.  Evolution of antigen receptor diversity.  Annual Fellows Forum, All Children's Hospital and University of South Florida College of Medicine, St. Petersburg, Fl, USA. (Oral presentation)

Dishaw, L.J., K. Nakamura, and S.L. Smith.  Nurse shark (Ginglymostoma Cirratum) C3 isoforms and implications for complement activity.  2003. 9th International Congress of the International Society of Developmental and Comparative Immunology, St. Andrews, Scotland.  

Bigger, C.H. and
L. J. Dishaw.  2003.  Immunophylogenetics from an invertebrate perspective.  9th International Congress of the International Society of Developmental and Comparative Immunology, St. Andrews, Scotland.  

Nakamura, K., D.-H. Shin,
L.J. Dishaw, and S.L. Smith.  2003.  C3 and factor I isoforms in the nurse shark, Ginglymostoma cirratum.  Annual Meeting and 90th Anniversary of the American Association of Immunologists, Denver, Co.  FASEB 17(7): 69.20.

H. Ramon,
L. J. Dishaw, M. Gomez, M. L. Herrera, and C.H. Bigger.  2003.  Molecular characterization of serine proteases in a coral.  Annual Meeting and 90th Anniversary of the American Association of Immunologists, Denver, Co.  FASEB 17(7): 36.10.

Smith, S.L., D.-H.Shin, 
L. J. Dishaw, and B.Webb. 2003.  Phylogenetic implications of two factor B-like genes from two shark species.  Annual Meeting and 90th Anniversary of the American Association of Immunologists, Denver, Co.  FASEB 17(7): 69.23.

Dishaw, L.J., K. Nakamura, and S.L. Smith.  2003.  Functional implications of two C3-isoforms in the Nurse Shark (Ginglymostoma cirratum).  Fifth Annual Comparative Immunology Symposium, FIU, Miami, Fl.  (Oral presentation)

Ramon, H. E.,
L. J. Dishaw, and C.H. Bigger. 2003.  Characterization of Galectin-like cDNAs in a coral.  Fifth Annual Comparative Immunology Symposium, FIU, Miami, Fl.  (Oral presentation)

Dishaw, L.J., C.H. Bigger, and S.L. Smith.  2002.  Ancient origins for the C3-like ancestor of complement components C3/C4/C5. International Immunopharmacology. 2(3): 1293. (Abstract from the XIX International Complement Workshop, Palermo, Italy).

Dishaw, L.J
., M.L. Herrera, S.L. Smith, and C.H. Bigger.  2002.  Evidence for an ancestral C3-like protein in a gorgonian coral, Swiftia exserta.  FASEB. 16(4): 510.6.  (Poster and published abstract, FASEB meeting)

Dishaw, L.J., M.L. Herrera, S.L. Smith, and C.H. Bigger.  2002. Evidence for an ancestral C3-like protein in a gorgonian coral, Swiftia exserta.  Fourth Annual Tropical Biology Research Symposium, FIU, Miami, Fl.  (Oral Presentation)  

Dishaw, L.J., S.L. Smith, and C.H. Bigger. 2001.  Sequence and phylogenetic analysis of partial cDNA clones from a coral, encoding a thiolester-containing A2M/C3-like protein.  FASEB. 15(4): 531.2.  (Poster and published abstract,  FASEB meeting)

Bigger, C.H.,
L. J. Dishaw, and C. Olano.  Immune defenses of the gorgonian coral, Swiftia exserta:  simple or complex?  8th Congress of the International Society of Developmental and Comparative Immunology. Cairns, Australia.  Developmental and Comparative Immunology 24(S1):  S43. (Oral presentation)

Dishaw, L.J., S.L. Smith,  and C.H. Bigger.  2000.  Sequence analysis of partial cDNA clones from a coral, encoding a thiolester-containing protein.  8th Congress of the International Society of Developmental and Comparative Immunology. Cairns, Australia.  Developmental and Comparative Immunology 24(S1): S23. (Oral presentation)

Dishaw, L. J. and C.H. Bigger.  2000.  Microsatellite Anchored DNA-fingerprinting in a Gorgonian Coral, Swiftia exserta. Second Annual Tropical Biology Research Symposium, FIU, Miami, Fl.  (Oral Presentation)

Bigger, C.H., C. Olano, and
L.J. Dishaw.  1999.  Mechanisms of allograft rejection in the gorgonian coral Swiftia exserta.  Mid Atlantic Society of Developmental and Comparative Immunology.  Washington, D.C.

Dishaw, L. J.
and C.H. Bigger.  1999.  Microsatellite Anchored DNA-fingerprinting in a Gorgonian Coral, Swiftia exserta.  Mid Atlantic Society of Developmental and Comparative Immunology.  Washington, D.C. (Oral Presentation)

Dishaw, L. J. and C.H. Bigger. 1999. Coral Microsatellite DNA.  First Annual Biology Research Symposium, FIU, Miami, Fl. (Oral Presentation)